Two England stars ruled out of Autumn and the Six Nations

SECOND-ROW:

• 4. Maro Itoje (Saracens, 52 caps)
• 5. Courtney Lawes (Northampton Saints, 91 caps)

BACK-ROW:

• 6. Tom Curry (Sale Sharks, 34 caps)
• 7. Sam Underhill (Bath Rugby, 22 caps)
• 8. Alex Dombrandt (Harlequins, 1 cap)